lactacystin助记

Conclusion: There is synergistic toxic effect between lactacystin and paraquat and the chronic exposure to paraquat can increase the risk for PD of rats with lightly impaired proteasome.

结论：lactacystin与PQ之间存在协同作用，长期小剂量PQ的暴露能显著增加蛋白酶体功能轻微损害的大鼠患PD的风险。

PD rats that expressed Lewy body and presented lateral rotation were made by injecting 8 μ g lactacystin into one side of substantia nigra compact part of rat with stereotaxic technique.

在大鼠单侧黑质致密部（SNc）立体定向注射蛋白酶体抑制剂lactacystin8μg，建立表达Lewy小体并向偏侧旋转的PD大鼠。

Conclusion The rat model of Parkinson's disease with Lewy body is set up by using Lactacystin which can block the α-synuclein degradation.

结论利用蛋白酶体抑制剂Lactacystin阻碍α-synuclein的降解可以建立有Lewy体的PD大鼠模型。